Clinical biochemistry and advanced assessment in nutrition

Please answer those two question (the pages required to aster are attached, and you can use other online professional resources as well)

1. Compare the Pyruvate Dehydrogenase Complex (Lord Figure 6.4 p.332, (read 331-334) to the Branched Chain Ketoacid Dehydrogenase Complex Lord Figure 6.8 p.342 (read341344) and Lord Figure 4.12 p.207 (read 205207). How are they similar and different in terms of functionality and nutrient requirements. What organic acids are elevated when there is insufficient activity of these two enzyme complexes?

2. Read the section on Biotin, Lord p344-347. How does biotin relate to multiple carboxylase deficiency (MCD)? What are the symptoms and organic acid markers of biotin deficiency?

Reference:
1. Laboratory Evaluations for Integrative and Functional Medicine, 2nd Edition
By Richard S. Lord & J. Alexander Bralley
Metametrix Institute Hardcover, Published May 2008, ISBN: 978-0-9673949-4-5 ($200.00 at Metametrix)