Drug profile of pharmacology ( Naloxone )
My drug profile about Naloxone
1. Begin your drug profile by stating the chemical name, generic name, and the Australian trade names for your chosen drug.
2. a. List the approved indications for your drug.
b. Determine whether your drug is approved for paramedic use in your state, and if it is, list the approved paramedic indications for your drug.
Section 4: Over-The-Counter & Complementary and Alternative Medicines
3. Add to your drug profile:
1. A list of conventional over-the-counter (OTC) medicines, complementary alternative medicines (CAMs) and prescription medicines that are known or suspected to undergo clinically relevant interactions with your profile drug IN HUMANS.
2. List the source(s) of information you have used and indicate the strength of the evidence (e.g. anecdotal report, clinical case, clinical trial, etc) for each of the interactions that you have identified.
For your chosen drug:
1. Describe the mechanism of action. Your answer should:
1. Identify how the interaction of the drug with its molecular target(s) accounts for the major therapeutic effect (i.e. the effect you want the drug to cause in clinical practice; e.g. for paracetamol pain relief)
2. Include a description of how the drug alters function at the cellular level.
3. Include a description of how the altered cellular function manifests as a change in body system function, and the eventual major therapeutic response
2. Critically review 2 ORIGINAL RESEARCH PEER REVIEWED journal articles that provide evidence for the clinical effectiveness of your drug IN HUMANS. Your response should identify and critique the:
0. Type of study (e.g. randomised control trial, anecdotal report, etc).
1. Comparator agent (e.g. placebo, current gold standard therapy, etc).
2. Sample size (the number of study participants).
3. Measures of effectiveness.
On the basis of this critique, briefly summarise your interpretation of the evidence for the effectiveness of your drug.
Section 1. Renal Excretion of Drugs and their Metabolites
5. At this stage for your chosen drug ascertain if:
a? It is excreted unchanged (as parent drug) in urine.
a? It is excreted in urine principally as metabolites.
Section 2. Drug Metabolism
6. For your chosen drug:
1. Using a diagram (if possible) as an aid discuss its metabolism noting the types of reactions, that is either functionalisation or conjugation reactions, and identify the involvement of any CYP, UGT or other drug metabolising enzymes.
2. Identify the main metabolites (note those on your figure), and state the percent of the parent compound metabolised to the specific metabolite.
Section 3. Sources of variability in drug metabolism
7. In relation to the metabolism of your drug: discuss the influence of host (e.g. disease states) and environmental factors in terms of enzyme induction and/or inhibition on the metabolism of your drug.
Section 4. Drug-Drug Interactions
8. For your drug:
1. List all known drug-drug interactions involving the metabolism of your drug.
2. Explain the mechanism of each of the interactions (i.e. Drug A inhibits the metabolism of Drug B by Enzyme X)
Note the clinical consequences of each of the interactions. (e.g. increases the plasma drug concentration of Drug B leading to an enhanced pharmacological effect and toxicity).