ENETICS UNIT 7 ASSIGNMENT (Unit 7: Genomics and Genetic Engineering)

Numerous diseases are caused by problems in DNA replication. For example, Bloom Syndrome is caused by a mutation in one of the helicase enzymes involved in DNA replication. Select one of the enzymes involved in DNA replication or repair and find a disease related to a mutation in this enzyme (a few of these diseases are mentioned in your textbook). In a 2-3 page paper, address the following topics:
Assignment
Textbook Information

Title: Genetics Essentials: Concepts and Connections (e-book)

Author: Benjamin A. Pierce

ISBN: 1-4292-3040-7

Publisher: W.H. Freeman and Company

MAY INCLUDE OTHER SOURCES AS REFERENCES
SC435-2: Elaborate the principles of molecular genetics including DNA structure and replication, transcription, translation, genomics, and genetic manipulations
FOR THIS ASSIGNMENT I CHOOSE: BLOOM SYNDROME
1.What is the mutation, how does this mutation impact DNA replication?
2.How was the relationship between the mutation and the disease discovered?
3.What are the symptoms of the disease?
4.How does the problem in DNA replication lead to the symptoms of the disease (a discussion of transcription and/or translation may be appropriate here)?
5.How could genetic engineering technology be used to learn more about this disease?
You should write this assignment as an integrated paper that addresses all the questions. This assignment should not be done in question and answer format. Be sure to use appropriate headings for each section of the paper.

Basic Writing Expectations:

1.Your report should be between 2-3 pages, not counting the title or reference pages.
2.Include a title page, double space, font size 10 or 12 in APA format.
3.Include a highly developed viewpoint/thesis, purpose, and exceptional content.
4.Demonstrate superior organization: use logic.
5.Make certain that your paper is free of grammar and spelling errors.
6.Avoid plagiarism.
7.Use APA style for all citations.
8.Always include an introduction and conclusion.
GRADING RUBRICS: Note: Assessment for this outcome will be based on the Unit 7 Assignment.

Not Applicable

No work was received by the instructor.

No Progress

0
Student work demonstrates no understanding or progress towards achievement of this outcome.

Introductory

1
Student work demonstrates the ability to recognize the existence of the basic genetic structures and processes involved in DNA replication, transcription, translation, gene regulation, genomic analysis and genetic engineering. The student does not demonstrate awareness of the molecules involved (inputs and products) in these basic genetic processes.

Emergent

2
Student work demonstrates an understanding of the molecular inputs and products involved in the basic genetic structures and processes involved in DNA replication, transcription, translation, gene regulation, genomic analysis and genetic engineering. The student does not demonstrate an understanding of the enzymatic and cellular mechanisms involved in these basic genetic processes.

Practiced

3
Student work demonstrates an understanding of the enzymatic and cellular mechanisms involved in the basic genetic structures and processes involved in DNA replication, transcription, translation, gene regulation, genomic analysis and genetic engineering. The student does not demonstrate an understanding of the cellular/organismal/technological context (purpose or effect on the cell/organism/technology) of each genetic process.

Proficient

4
Student work demonstrates an understanding of the cellular/organismal/technological context (purpose or effect on the cell/organism) of the basic genetic structures and processes involved in DNA replication, transcription, translation, gene regulation, genomic analysis and genetic engineering in isolation from one another. The student does not demonstrate an understanding of the inter-relatedness among these processes and their overall relevance/effects on the organism.

Mastery

5
Student work demonstrates an understanding of the inter-relatedness among the basic genetic structures and processes involved in DNA replication, transcription, translation, gene regulation, genomic analysis and genetic engineering and of their overall relevance/effects.

SC435-3: Apply the principles of genetic variation including mutation, DNA repair, population genetics, and multifactorial traits.

Evaluation Criteria

This rubric assesses the studentas ability to comprehend genetic basis of dominant and recessive genes in human diseases. It moves up Bloomas hierarchy from the most basic recognition (introductory) to describe observations (emergent), to making conclusions (practiced), to analysis of these findings (proficient). The mastery level is reserved for student work that exceeds expectations and includes no errors.