Iscuss the laboratory development of cardiac markers used in the investigations of patients with suspected acute myocardial infarction

3MED569 Biology of Disease
Coursework assessment 1: an essay of 900-1000 words (excluding references/table); please note extracts below from module handbook:
a?The coursework essay will require students to extrapolate, explain and understand processes in pathology of a named disorder using information derived from the scientific literature. All written work should be presented using accurate, appropriate English with acknowledged sources following the Harvard system (learning outcomes 2 and 3).a
a?The essay assessment provides an opportunity for students to research and to describe cellular and molecular alterations of a disease process (learning outcomes 2, 3, 5 and 8).a
Please note the first 2 assessment criteria will be generic a on referencing, standard of English and essay presentation.
Essay title:
Discuss the laboratory development of cardiac markers used in the investigations of patients with suspected acute myocardial infarction

Key references:

1 Randomised Assessment of Treatment using Panel Assay of Cardiac markers--Contemporary Biomarker Evaluation (RATPAC CBE). Collinson PO, Gaze DC, Thokala P, Goodacre S. Health Technol Assess. 2013;17(15):v-vi, 1-122. doi: 10.3310/hta17150.

2. Analytical characteristics of high-sensitivity cardiac troponin assays.Apple FS, Collinson PO; IFCC Task Force on Clinical Applications of Cardiac Biomarkers. Clin Chem. 2012 Jan;58(1):54-61. doi: 10.1373/clinchem.2011.165795. Epub 2011 Sep 30. Review. Erratum in: Clin Chem. 2012 Apr;58(4):796.

3. Age-dependent values of N-terminal pro-B-type natriuretic peptide are superior to a single cut-point for ruling out suspected systolic dysfunction in primary care.. Hildebrandt P, Collinson PO, Doughty RN, Fuat A, Gaze DC, Gustafsson F, Januzzi J, Rosenberg J, Senior R, Richards M. Eur Heart J. 2010 Aug;31(15):1881-9. doi: 10.1093/eurheartj/ehq163. Epub 2010 Jun 2. Review.

4. Novel biomarkers for risk stratification and identification of life-threatening cardiovascular disease: troponin and beyond. Razzouk L, Fusaro M, Esquitin R. Curr Cardiol Rev. 2012 May;8(2):109-15. Review.

5. Emerging biomarkers in heart failure. van Kimmenade RR, Januzzi JL Jr.Clin Chem. 2012 Jan;58(1):127-38. doi: 10.1373/clinchem.2011.165720. Epub 2011 Nov 15. Review.
Assessment criteria:
1a¦a¦..Referencing

2a¦a¦..Standard of English and presentation

3. mechanisms involved in the development of atherosclerosis (200 words)

4 Discuss the effectiveness of protein & enzyme markers in terms of sensitivity and specificity in identifying myocardial infarction

5 Discuss the identification of new cardiac markers for heart disease