Istory middle age to early modern world

what is to you the most important development or event (of any kind) marking the passage from the Middle Ages to the Early Modern world? Give your reasons for his making this choice. Be certain to contextualize your answer by connecting this event or development to its past and future( diachronic analysis) and/or to contemporaneous developments(synchronic analysis)

I want to answer question that the fall of constantinople was the most important event because I am Turkish and contantinople was the most important city by that time also it was the center of Christianity, You can also connect this to anything you want. For example you can include crusades.
Thank you