Orensic Biomolecules Essay  Molecular and Biochemical Mechanisms of Analgesic Response to Morphine and Other Opioids

Forensic Biomolecules Essay

 Molecular and Biochemical Mechanisms of Analgesic Response to Morphine and Other Opioids
Assignment detail:
Discuss, including the key enzymes and encoding genes, the mechanisms of morphine in pain relief.
You should cover:
” glucuronidation of morphine (the morphine metabolites), the enzyme uridine diphosphate glycosyltransferase (UGT2B7) and the key SNPs affecting its function.
” Chemical structures of M6G and M3G and their different analgesia potency.
” Chemical structures of various opioids, such as morphine, codeine, fentanyl, heroin, levorphanol and methadone (you can copy the chemical structures from ).
” Opioid receptors, such as OPMR1 and its isomers, and the key SNPs affecting the binding to morphine, M6G and other opioid molecules (such as codeine, codeine glucuronide) as well as -endorphin.
” M6G clearance pathway by ABC-type of transporter, MRP3.
” Elation with COMT gene and protein, as well as key SNPs.
” Biological implications of mutations on any of the genes involved, such as analgestic response to opioid molecules.
” Population relevance of the key SNPs on each of the genes.
” Population relevance in terms of analgestic response to difference opioids, such as the comparison of morphine with codiene.
” Isomers of each type of proteins involved in the analgestic response to opioids.
” Protein sequence alignments in aid of explaining the molecular mechanisms.
” Use tables and diagrams (Figures) for efficient discussions and arguments.
” You need to reference peer-reviewed scientific papers, you should read and reference from NCBI PubMed.
reference peer-reviewed scientific papers
You must use Harvard Referencing system