Pigenetic modification in human thyroid cancer
In 6-7 pages single space write your paper on Epigenetic modification in human thyroid cancer and follow the description bellow
Epigenetics Paper: Below is a description of the content that must be in your paper.
Define epigenetics (this will require more than a single sentence. You will need to talk about regulation and transgenerational effects).
Epigenetic mechanisms (how do you get an epigenetic mark, what do they do, and what are common epigenetic marks, sequences and structures).
Describe how researchers study epigenetics (how do you identify epigenetic marks, and how do you analyze the data).
Describe how epigenetics influences development.
Describe how epigenetics influences cancer.
Describe how epigenetics influences neurobiology (Alzheimers, Autism, stress, mood, and memory).
Describe how epigenetics influences the gut microbiota and the gut-brain axis.
Describe how epigenetics influences metabolism (obesity and diabetes).
Describe how epigenetics influences immunity.
You must use all of the papers that have been assigned this semester.
You must use all of the papers found by your group, and you must go into greater depth on your group topic.
Added on 29.03.2015 14:41
Irizarry, R. A., et al. (2008). Comprehensive high-throughput arrays for relative methylation (CHARM).Genome Res 18(5): 780-790.
-This article describes the CHARM array. You may want to review what you have learned previously about micro-arrays. The following video from the DNA Learning Center, Cold Springs Harbor Laboratory, is a quick refresher: 16929!/menu/main/topColumns/topLeftColumn/pdf/518273a.pdf
This is a one page overview (easy to read).
Romanoski, C. E., Glass, C. K., Stunnenberg, H. G., Wilson, L., & Almouzni, G. (2015). Epigenomics: Roadmap for regulation. Nature, 518(7539), 314-316.
This is a forum. It is a three page overview of what this issue of Nature will focus upon (easy to read).
This is currently open access: full/518314a.html
Gjoneska, E., Pfenning, A. R., Mathys, H., Quon, G., Kundaje, A., Tsai, L. H., & Kellis, M. (2015). Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer/S disease. Nature, 518(7539), 365-369.
This article is currently open: full/nature14252.html
For Wednesday, March 4th (read both articles)
Kundaje, A., Meuleman, W., Ernst, J., Bilenky, M., Yen, A., Heravi-Moussavi, A., … & Kulkarni, A. (2015). Integrative analysis of 111 reference human epigenomes. Nature, 518(7539), 317-330.
This article is currently open access: full/nature14248.html
Tsankov, A. M., Gu, H., Akopian, V., Ziller, M. J., Donaghey, J., Amit, I., … & Meissner, A. (2015). Transcription factor binding dynamics during human ES cell differentiation. Nature, 518(7539), 344-349.
This artice is currently open access: full/nature14233.html
Editorial: Beyond the Genome html