Rtically evaluate the use of Immunocytochemistry in the search for the identity of the Unknown primary”

Background
Sometimes patients will present with distinct tumours that carry a high index of suspicion that they might be of distant, metastatic origin rather than primary tumours. In such cases, the clinical context and/or histological morphology of the tumour may make it difficult to establish the origin of the tumour. In this essay you are expected to outline how immunocytochemistry can be used to confirm the identity of the primary tumour. You should use illustrative examples to explain the basis of this approach and discuss its advantages and limitations.
Threshold criteria
a? Explanation of the meaning of a?primarya? and a?metastatica?
a? Definition of ICC
a? Use of antibodies against biomarkers tumour or lineage specific
a? Absence of plagiarism
Grading criteria
a? Explanation of the problem in context
a? Single antibodies v panels
a? Diagnostic algorithms
a? ICC results must be analysed in conjunction with morphology and clinical
context
a? Cost
a? Not all tumours can be effectively distinguished with existing panels

Essay guidance
The essay will provide an opportunity for you to demonstrate a detailed understanding of selected aspects of cellular pathology. You will be expected to demonstrate ability in selective information retrieval and the presentation of ideas within a logical and coherent structure.
a? The essay should be no more than 1000 words in length (excluding references and any figure legends).
a? The essay should be word processed in 12 pt Times New Roman or Arial font and with double-line spacing.
a? Use subheadings where appropriate to make clear the structure and intent of your essay.
a? References should be listed at the end of the essay. All sources must be referenced. You should use the Harvard system for reference citation:
include a photocopy of the first page of each of your principle
journal references
a? Plagiarism a you are reminded that you must adhere to the Academic Regulations on plagiarism. This information can be found on the Academic Registraras Department page on the University intranet site.

COULD THE WRITER PLEASE USE A MINIMUM OF 4/5 JOURNALS AND ALSO FORWARD THE PRINCIPLE JOURNALS USED AS ATTACHMENTS IN WRITING THE ESSAY AS I WILL NEED TO SUBMIT THE FIRST PAGE OF EACH OF THE REFERENCES. IM REQUESTING THIS BECAUSE ALTHOUGH A BIBLIOGRAPHY WILL BE INCLUDED IT DOES NOT GUARANTEE THAT I WILL HAVE ACCESS TO THE JOURNALS USED OR I MAY NOT BE ABLE TO LOCATE THEM BUT I WILL NEED TO PRINT THE FIRST PAGES IN ORDER FOR THE ESSAY TO BE MARKED AT ALL. Many thanks Mary